The
most cutting edge fat burners to ever hit the market...
THE BURN is backed by incredible science! The
following scientific references are studies that helped Fizogen
researchers in the development of these two amazing product
technologies! Real science has been put into THE BURN formulas
to give you incredible results!
Synephrine
HCL:
Haaz S, Fontaine KR, Cutter
G, Limdi N, Perumean-Chaney S, Allison DB. Citrus aurantium and
synephrine alkaloids in the treatment of overweight and obesity:
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Min B, Cios D, Kluger
J, White CM. Absence of QTc-interval-prolonging or hemodynamic
effects of a single dose of bitter-orange extract in healthy subjects.
Pharmacotherapy. 2005 Dec;25(12):1719-24.
Inhibition of human CYP3A4
activity by grapefruit fl avonoids, furanocoumarins and related
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2001 Sep-Dec;4(3):217-27.
In vitro inhibition of
simvastatin metabolism in rat and human liver by naringenin. Ubeaud
G, Hagenbach J, Vandenschrieck S, Jung L, Koffel JC. Life Sci.
1999;65(13):1403-12.
The character of inhibition
of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice
in human. Runkel M, Bourian M, Tegtmeier M, Legrum W. Eur J Clin
Pharmacol. 1997;53(3-4):265-269.
Metabolic and analytical
interactions of grapefruit juice and 1,2-benzopyrone (coumarin)
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Tegtmeier M, Legrum W. Eur J Clin Pharmacol. 1996;50(3):225-30.
The fate of naringin in
humans: a key to grapefruit juice-drug interactions? Fuhr U, Kummert
AL. Clin Pharmacol Ther. 1995 Oct;58(4):365-73.
Inhibitory effect of grapefruit
juice and its bitter principal, naringenin, on CYP1A2 dependent
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J Clin Pharmacol. 1993 Apr;35(4):431-6.
Haller CA, Benowitz NL,
Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements
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Yohimbine
HCL:
McCarty MF. Pre-exercise
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2002 Jun;58(6):491-5.
Differential function
of the alpha2A-adrenoceptor and Phosphodiesterase-3B in human adipocytes
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Gomez-Ambrosi J, Fruhbeck
G, Aguado M, Milagro FI, Margareto J, Martinez AJ. Divergent effects
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Guggulsterone
Z & E
Thyroid Stimulating Action
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Thyroid Stimulatory Action
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Hypolipidemic and Antioxidant
Effects of Commiphora Mukul as an Adjunct to Dietary Therapy in
Patients with Hypercholesterolemia. Singh R, Niaz M, Ghosh S. Cardiovascular
Drugs and Therapy (1994) 8:659-664
1962;56:76-82
Effect of Commiphora Mukul
(Gum Guggulu) in Patients of Hyperlipidemia with Special reference
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1988:356-360
Gum Guggul (Commiphora
Mukul)-The Success Story of an Aincient Insight Leading to a Modern
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Simultaneous Determination
of E&Z Guggsterones in Dietary Supplements Containing Commiphora
Mukuk Extract (Guggulipid) by Liquid Chromatography. Nagarajan
M, Waszkuc T, Sun J. Jour AOAC Int (2001) Jan-Feb; 84(1):24-28
High Performance Liquid
Chromatography Method for Fingerprinting and Quantitative Determination
of E&Z Guggulsterones in Commiphora Mukul Resin and its Products.
Mesrob B, Nesbitt C, Misra R, Pandey R. J Chromatogr B Biomed Sci
Appl (1998) Dec 11;720 (1-2):189-196
Caffeine
USP:
Westerterp-Plantenga MS,
Lejeune MP, Kovacs EM. Body weight loss and weight maintenance
in relation to habitual caffeine intake and green tea supplementation.
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Ryu S, Choi SK, Joung
SS, Suh H, Cha YS, Lee S, Lim K. Caffeine as a lipolytic food component
increases endurance performance in rats and athletes. J Nutr Sci
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Wilcox AR. The effects
of caffeine and exercise on body weight, fat-pad weight, and fat-cell
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Arciero PJ, Gardner AW,
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ingestion on NE kinetics, fat oxidation, and energy expenditure
in younger and older men. Am J Physiol 1995;268:E1192-8.
Zhang Y, Wells JN. The
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receptors. J Pharmacol Exp Ther 1990;254:757-63.
Hetzler RK, Knowlton RG,
Somani SM, Brown DD, Perkins RM, 3rd. Effect of paraxanthine on
FFA mobilization after intravenous caffeine administration in humans.
J Appl Physiol 1990;68:44-7.
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Evodiamine
Capsaicin-Like Anti-Obesity
Activities of Evodiamine From Fruits of Evodia Rutaecarpa, a Vanilliod
Receptor Agonist. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K,
Yokoo Y, Kamiya T. Planta Med. 2001 Oct; 67(7): 628-633
Antianoxic Action of Evodiamine,
an Alkaloid in Evodia Rutaecarpa Fruit. Yamahara J, Yamada T, Kitani
T, Naitoh Y, Fujimura H. J Ethnopharmacol. 1989 Nov; 27(1-2): 185-192
Inhibitory Effect of Evodiamine
on Aldosterone Release by Zona Glomerulosa Cells in Male Rats.
Hung PH, Lin LC, Wang GJ, Chen CF, Wang PS. Clin J Physiol. 2001
Jun 30; 44(2): 53-57
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Active Constituents of Evodia Fructus. Yamahara J, Yamada T, Kitani
T, Naitoh Y, Fujimura H. Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1820-1822
Advances in Pharmacological
Study of Evodia Rutaecarpa and its Effective Constituents. Zhong
Yao Cai. 2003 Apr;26(4):295-298
Naringin
Fuhr U, Maier A, Keller
A, Steinijans VW, Sauter R, Staib AH. Lacking effect of grapefruit
juice on theophylline pharmacokinetics. Int J Clin Pharmacol Ther.
1995 Jun;33(6):311-4.
Fuhr U, Klittich K, Staib
AH. Inhibitory effect of grapefruit juice and its bitter principal,
naringenin, on CYP1A2 dependent metabolism of caffeine in man.
Br J Clin Pharmacol. 1993 Apr;35(4):431-6.
L-Taurine-Ethyl-Ester-HCL:
Seidl R, Peyrl A, Nicham
R, Hauser E. A taurine and caffeine-containing drink stimulates
cognitive performance and well-being. Amino Acids. 2000;19(3-4):635-42.
Reyner LA, Horne JA. Effi
cacy of a ‘functional energy drink’ in counteracting
driver sleepiness. Physiol Behav. 2002 Mar;75(3):331-5.
Glucuronolactone and Glucose
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L-Gulonolactone and Penitols on Insulin Secretion in Dogs. Kuzuya
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Effects of Glucuronolactone
and the Other Carbohydrates on the Biochemical Changes Produced
in the Living Body of Rats by Hard Exercise. Tamura S, Tsutsumi
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Di-Caffeine
Malate
Exercise-Induced Alterations
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The Role of Malate in
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245, No. 2, March: 470-476
Effect of Malic Acid Salts
on Physical Working Capacity and its Restoration After Exhausting
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S. Farmakol Toksikol (1988) May-Jun; 51(3):21-25
Treatment of Fibromyalgia
Syndrome with Super Malic: a Randomized, Double Blind, Placebo
Controlled, Crossover Pilot Study. Russell IJ, Michalek JE, Flechas
JD, Abraham GE. J Rheumatol. 1995 May;22(5):953-8
MEN’S
Formula
7-Beta-Hydroxy-DHEA
Lardy H, Marwah A, Marwah
P.C(19)-5-ene steroids in nature. Vitam Horm. 2005;71:263-99.
Review. Ergosteroids IV:
Synthesis and Biological Activity of Steroid Glucuronosides, Ethers,
and Alkylcarbonates. Marwah P, Marwah A, Kneer N, Lardy H. Steroids
66 (2001) 581-595
DHEA and DHEA-S: A Review.
Kroboth P, Salek F, Pittenger A, Fabian T. J Clin Pharmacol 1999;39:327-348
The Importance of Being
Dehydroepiandrosterone Sulfate (In The Blood of Primates). Roberts
E. Biochem Pharmacol 1999;57:329-346
7-Hydroxylation of Dehydroepiandrosterone
By Rat Liver Homogenate. Starka L, Kutova J. Biochem Biophys Acta
1962;56:76-82
Studies of the Enzyme
Complex Responsible for Pregnelone and Dehydroepiandrosterone 7a-Hydroxylation
in Mouse Tissues. Doostzadeh J, Morfi n R. Steroids 1996;61:613-620
Ergosteroids II: Biologically
Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone.
Lardy H, Kneer N, Wei Y, Partridge B, Marwah P. Steroids 1998;63:158-165
An Acute Oral Gavage Study
of 3ß-acetoxyandrost-5-ene-7,17-dione (7-oxo-DHEA-acetate)
In Rats. Lardy H, Henwood S, Weeks C. Biochem Biophys Res Commun
1999;254:120-123
An Escalating Dose Oral
Gavage Study of 3ß-aceoxyandrost-5-ene-7,17-dione (7-oxo-DHEA-acetate)
in Rhesus Monkeys. Henwood S, Weeks C, Lardy H. Biochem Biophys
Res Commun 1999;254:124-126
Safety and Pharmacokinetic
Study With Esccalating Doses of 3-acetyl-7-oxo-DHEA in Healthy
Male Volunteers. Davidson M, Marwah A, Sawchuk R, Maki K, Marwah
P, Weeks C, Lardy H. Clin Investigative Med 2000 Oct;23(5):300-310
20-Beta-Hydroxy-Ecdysone-2-Acetate-Ester
Uchiyama, M, and T Yoshida.
1974, Effect of ecdysterone on carbohydrate and lipid metabolism:
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Syrov, VN, V Saatov, ShSh
Sagdullaev, and AU Mamatkhanov. 2001, Study of the structure – anabolic
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35 667–671.
Syrov, VN. 1984, Mechanism
of the anabolic action of phytoecdysteroids in mammals: Biologichekie
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WOMEN’S
Formula
Phosphatidylserine
Kingsley MI, Wadsworth
D, Kilduff LP, McEneny J, Benton D. Effects of soy lecithin phosphatidic
acid and phosphatidylserine complex (PAS) on the endocrine and
psychological responses to mental stress. Stress. 2004 Jun;7(2):119-26.
Benton D, Donohoe RT,
Sillance B, Nabb S. The infl uence of phosphatidylserine supplementation
on mood and heart rate when faced with an acute stressor. Nutr
Neurosci. 2001;4(3):169-78.
Daidzen
Wu J, Oka J, Higuchi M,
Tabata I, Toda T, Fujioka M, Fuku N, Teramoto T, Okuhira T, Ueno
T, Uchiyama S, Urata K, Yamada K, Ishimi Y. Cooperative effects
of isofl avones and exercise on bone and lipid metabolism in postmenopausal
Japanese women: a randomized placebo-controlled trial. Metabolism.
2006 Apr;55(4):423-33.
Ross JA, Kasum CM. Dietary
fl avonoids: bioavailability, metabolic effects, and safety. Annu
Rev Nutr. 2002;22:19-34. Epub 2002 Jan 4. Review.
Ohno S, Shinoda S, Toyoshima
S, Nakazawa H, Makino T, Nakajin S. Effects of fl avonoid phytochemicals
on cortisol production and on activities of steroidogenic enzymes
in human adrenocortical H295R cells. J Steroid Biochem Mol Biol.
2002 Mar;80(3):355-63.
Kandulska K, Nogowski
L, Szkudelski T. Effect of some phytoestrogens on metabolism of
rat adipocytes. Reprod Nutr Dev. 1999 Jul-Aug;39(4):497-501.
Setchell KD, Lydeking-Olsen
E. Dietary phytoestrogens and their effect on bone: evidence from
in vitro and in vivo, human observational, and dietary intervention
studies. Am J Clin Nutr. 2003 Sep;78(3 Suppl):593S-609S. Review.
These
statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent
any disease. For best results, use in conjunction with a well balanced,
calorie reduced diet and regular exercise program. Individual results
may vary.
