Appendix: Scientific References

THE BURN, THE BURN and Dietary Supplements References THE BURN is backed by incredible science! The following scientific references are studies that helped Fizogen researchers in the development of these two amazing product technologies! Real science has been put into THE BURN formulas to give you incredible results! Synephrine HCL: Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev. 2006 Feb;7(1):79-88 Min B, Cios D, Kluger J, White CM. Absence of QTc-interval-prolonging or hemodynamic effects of a single dose of bitter-orange extract in healthy subjects. Pharmacotherapy. 2005 Dec;25(12):1719-24. Inhibition of human CYP3A4 activity by grapefruit fl avonoids, furanocoumarins and related compounds. Ho PC, Saville DJ, Wanwimolruk S. J Pharm Pharm Sci. 2001 Sep-Dec;4(3):217-27. In vitro inhibition of simvastatin metabolism in rat and human liver by naringenin. Ubeaud G, Hagenbach J, Vandenschrieck S, Jung L, Koffel JC. Life Sci. 1999;65(13):1403-12. The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. Runkel M, Bourian M, Tegtmeier M, Legrum W. Eur J Clin Pharmacol. 1997;53(3-4):265-269. Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man. Runkel M, Tegtmeier M, Legrum W. Eur J Clin Pharmacol. 1996;50(3):225-30. The fate of naringin in humans: a key to grapefruit juice-drug interactions? Fuhr U, Kummert AL. Clin Pharmacol Ther. 1995 Oct;58(4):365-73. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Fuhr U, Klittich K, Staib AH. Br J Clin Pharmacol. 1993 Apr;35(4):431-6. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med. 2005 Sep;118(9):998-1003. Yohimbine HCL: McCarty MF. Pre-exercise administration of yohimbine may enhance the effi cacy of exercise training as a fat loss strategy by boosting lipolysis. Med Hypotheses. 2002 Jun;58(6):491-5. Differential function of the alpha2A-adrenoceptor and Phosphodiesterase-3B in human adipocytes of different origin. Int J Obes (Lond). 2005 Dec;29(12):1413-21. Gomez-Ambrosi J, Fruhbeck G, Aguado M, Milagro FI, Margareto J, Martinez AJ. Divergent effects of an alpha2-adrenergic antagonist on lipolysis and thermogenesis: interactions with a beta3-adrenergic agonist in rats. Int J Mol Med. 2001 Jul;8(1):103-9. Guggulsterone Z & E: Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora Mukul. Tripathi Y, Tripathi S, Malhotra O. Planta Medica (1984):78-80 Thyroid Stimulatory Action of (Z)-Guggulsterone: Mechanism of Action. Tripathi Y, Tripathi P, Malhotra O, Tripathi S. Planta Medica (1988):271-276 Hypolipidemic and Antioxidant Effects of Commiphora Mukul as an Adjunct to Dietary Therapy in Patients with Hypercholesterolemia. Singh R, Niaz M, Ghosh S. Cardiovascular Drugs and Therapy (1994) 8:659-664 1962;56:76-82 Effect of Commiphora Mukul (Gum Guggulu) in Patients of Hyperlipidemia with Special reference to HDL-Cholesterol. Verma S, Bordia A. Indian J Med Res 87, Apr 1988:356-360 Gum Guggul (Commiphora Mukul)-The Success Story of an Aincient Insight Leading to a Modern Discovery. Satyavati G. Indian J Med Res (1988): 327-335 Simultaneous Determination of E&Z Guggsterones in Dietary Supplements Containing Commiphora Mukuk Extract (Guggulipid) by Liquid Chromatography. Nagarajan M, Waszkuc T, Sun J. Jour AOAC Int (2001) Jan-Feb; 84(1):24-28 High Performance Liquid Chromatography Method for Fingerprinting and Quantitative Determination of E&Z Guggulsterones in Commiphora Mukul Resin and its Products. Mesrob B, Nesbitt C, Misra R, Pandey R. J Chromatogr B Biomed Sci Appl (1998) Dec 11;720 (1-2):189-196

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